In this episode of the Functional Medicine Institute Podcast, host Amber Warren sits down with Dr. Mark Holthouse to explore how a functional medicine approach transforms weight loss and metabolic health. Traditional advice like “eat less, move more” often fails, leaving patients frustrated, but weight loss resistance is rarely about willpower.

Amber and Dr. Holthouse break down the science behind FMI’s 12-month Premier Weight Loss Program, addressing the true drivers of weight challenges, including hormone imbalances, cortisol dysregulation, gut microbiome health, environmental toxins, and muscle loss. They explain why protein intake, body composition, and strength training matter more than the scale and share practical strategies to support sustainable fat loss.

The episode also covers GLP-1s and peptide therapies, including natural ways to support these pathways through nutrition, fiber, and gut health. Listeners will gain actionable insights to improve insulin sensitivity, preserve lean muscle, optimize metabolism, and create lasting results; all within a personalized, science-backed functional medicine framework.